THE EFFECT OF ETOMOXIR ON INSULIN SENSITIVITY IN TYPE-2 DIABETIC-PATIENTS

被引：38

作者：

HUBINGER, A ^{[1
]}

WEIKERT, G ^{[1
]}

WOLF, HPO ^{[1
]}

GRIES, FA ^{[1
]}

机构：

[1] BYK GULDEN LOMBERG CHEM FABR GMBH, PHARMACEUT, CONSTANCE, GERMANY

来源：

HORMONE AND METABOLIC RESEARCH | 1992年 / 24卷 / 03期

关键词：

CPTI-INHIBITOR; INSULIN RESISTANCE; TYPE-2; DIABETES-MELLITUS; ETOMOXIR;

D O I：

10.1055/s-2007-1003271

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Oral application of 50 mg Etomoxir caused a significant rise (33.1%) of insulin-mediated glucose uptake. This was shown in a placebo-controlled, double-blind randomized study in 8 type 2 diabetic patients by using the euglycemic clamp technique. The mean metabolic clearance rate of glucose (MCR) was raised from 4.1 +/- 0.9 mg/(kg.min) to 5.4 +/- 1.2 mg/(kg.min) (x +/- SEM, P = 0.039). Plasma levels of free fatty acids (FFA), glucose counterregulatory hormones, lipids and C-peptide values during the clamps were not different after verum and placebo. We conclude that Etomoxir improves insulin sensitivity in type 2 diabetic patients.

引用

页码：115 / 118

页数：4

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