COMPARATIVE MAPPING OF MOUSE CHROMOSOME-2 AND HUMAN CHROMOSOME-9Q - THE GENES FOR GELSOLIN AND DOPAMINE BETA-HYDROXYLASE MAP TO MOUSE CHROMOSOME-2

被引：25

作者：

PILZ, A ^{[1
]}

MOSELEY, H ^{[1
]}

PETERS, J ^{[1
]}

ABBOTT, C ^{[1
]}

机构：

[1] MRC,RADIOBIOL UNIT,DIDCOT OX11 0RD,OXON,ENGLAND

来源：

GENOMICS | 1992年 / 12卷 / 04期

关键词：

D O I：

10.1016/0888-7543(92)90300-H

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The mapping of human chromosome 9 (HSA9) and mouse chromosome 2 (MMU2) has revealed a conserved syntenic region between the distal end of the long arm of chromosome 9 and proximal mouse chromosome 2. Two genes that map to human chromosome 9q34, gelsolin (GSN) and dopamine β-hydroxylase (DBH), have not previously been located in the mouse. We have used an interspecific backcross to map each of these genes, by Southern blot analysis, to mouse chromosome 2. Gelsolin (Gsn) is tightly linked to the gene for complement component C5 (Hc), and dopamine β-hydroxylase (Dbh) is just proximal to the Abelson leukemia virus oncogene (Abl) and α-spectrin 2 (Spna-2). The loci for gelsolin and dopamine β-hydroxylase therefore form part of the conserved synteny between HSA9q and MMU2. © 1992.

引用

页码：715 / 719

页数：5

共 21 条

[1] THE HUMAN HOMOLOG OF THE MOUSE BROWN GENE MAPS TO THE SHORT ARM OF CHROMOSOME-9 AND EXTENDS THE KNOWN REGION OF HOMOLOGY WITH MOUSE CHROMOSOME-4 [J].