MODELING OF AMPEROMETRIC BIOSENSORS BY A FINITE-VOLUME METHOD

被引:16
作者
BACHA, S
BERGEL, A
COMTAT, M
机构
[1] Laboratoire de Génie Chimique, URA 192 CNRS, Laboratoire de Génie Chimique et Electrochimie, 31062 Toulouse Cédex
来源
JOURNAL OF ELECTROANALYTICAL CHEMISTRY | 1993年 / 359卷 / 1-2期
关键词
D O I
10.1016/0022-0728(93)80398-2
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A numerical model has been developed to analyze the transient response of amperometric enzyme biosensors. These sensors were composed of an inert metallic electrode covered by an enzyme layer which was either a free enzyme solution, confined by a semipermeable membrane, or an immobilized enzyme linked to one of the sides of a polymeric membrane placed against the electrode. The cases where the enzyme was linked to the outside and inside of the membrane are presented. The finite-volume method was used to solve the partial derivative equations coupling the diffusive mass transfer to enzymatic kinetics. This method makes it possible to adapt the discretization space grid easily to the geometry of the integration domain. The performance of the method is discussed by comparing it with the steady state analytical response and with the implicit finite-difference method.
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页码:21 / 38
页数:18
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