DOPAMINE-RECEPTORS IN THE BASAL GANGLIA - RELEVANCE TO PARKINSONS-DISEASE

被引：70

作者：

STRANGE, PG

机构：

[1] Biological Laboratory, The University, Canterbury, Kent

来源：

MOVEMENT DISORDERS | 1993年 / 8卷 / 03期

关键词：

DOPAMINE RECEPTORS; PARKINSONS DISEASE; DRUG TREATMENT; NEOSTRIATUM; MOTOR CONTROL;

D O I：

10.1002/mds.870080303

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

At least five receptors for dopamine (D1-D5) have been recognised from molecular biological studies, and their pharmacological properties and brain localisations have been determined. The D1 and D2 subtypes are the principal subtypes in brain, and their cellular localisations in the caudate nucleus and putamen have been determined. With recent advances in the understanding of basal ganglia neuronal function, these localisation data enable insights into the mode of action of drugs used at present and in the future to treat Parkinson's disease.

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页码：263 / 270

页数：8

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