ANTIANGINAL EFFECT OF ISOSORBIDE-5-MONONITRATE GIVEN AS MONOTHERAPY IN ANGINA-PECTORIS - A COMPARISON OF 2 DIFFERENT ONCE-DAILY FORMULATIONS

被引：1

作者：

DEEG, P

机构：

[1] Deegenberg-Klinik, Bad Kissingen, D-8730

来源：

DRUG INVESTIGATION | 1993年 / 6卷 / 04期

关键词：

D O I：

10.1007/BF03259248

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A randomised double-blind crossover study was performed in 48 patients with stable effort-induced angina pectoris to assess the antianginal and anti-ischaemic effects of 2 different controlled-release formulations of isosorbide-5-mononitrate (5-ISMN): 30mg 5-ISMN Durules(R) (Imdur(R)/Coleb-Duriles(R)) and the 40mg 5-ISMN tablet (Corangin(R)). Bicycle exercise tests were performed 4 hours postdose at the end of each 2-week treatment period. Time to end of exercise (means: 386 vs 366 seconds) and time to onset of angina (means: 313 vs 295 seconds) were significantly longer during treatment with 30mg 5-ISMN Durules(R) than during treatment with the 40mg 5-ISMN tablet.

引用

页码：231 / 236

页数：6

共 13 条

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