USE OF BOTULINUM TOXIN IN THE TREATMENT OF HAND DYSTONIA

被引:27
作者
JANKOVIC, J
SCHWARTZ, KS
机构
[1] Baylor College of Medicine, Department of Neurology, Parkinson's Disease Center, Houston, TX
来源
JOURNAL OF HAND SURGERY-AMERICAN VOLUME | 1993年 / 18A卷 / 05期
关键词
D O I
10.1016/0363-5023(93)90060-G
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Forty-six patients with hand dystonia, considered disabling despite optimal pharmacologic therapy, were injected in the forearm musculature with botulinum A toxin. Thirty of these patients were followed long enough to provide adequate data for analysis of 86 treatment sessions. There was a 63% female preponderance, with an average age at initial evaluation of 46 years and symptom duration of 7.9 years. Average baseline severity of dystonia was rated as 3.5 on a severity rating scale (0-4 rating; 4 = maximum severity). The average peak effect response for all injections (79 into wrist flexors and 29 into wrist extensors) was 2.2 for dystonia and 3.0 for pain (0-4 rating; 0 = no response, 4 = maximum benefit). The latency from injection to onset of effect averaged 5.6 days. Total response duration averaged 9.3 weeks and maximum improvement was 7.5 weeks. Only local complications occurred and consisted primarily of hand weakness (25 patients, 44 sessions). The results show that botulinum toxin injections effectively control hand dystonia in instances where other forms of therapy have failed.
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收藏
页码:883 / 887
页数:5
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