CATECHOLAMINERGIC FUNCTION AND P300 AMPLITUDE IN MAJOR DEPRESSIVE DISORDER (P300 AND CATECHOLAMINES)

被引：46

作者：

HANSENNE, M ^{[1
]}

PITCHOT, W ^{[1
]}

MORENO, AG ^{[1
]}

PAPART, P ^{[1
]}

TIMSITBERTHIER, M ^{[1
]}

ANSSEAU, M ^{[1
]}

机构：

[1] HOP PETIT BOURGOGNE, COGNIT PSYCHOPHYSIOL UNIT, B-4020 LIEGE, BELGIUM

来源：

EVOKED POTENTIALS-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY | 1995年 / 96卷 / 02期

关键词：

P300; NEUROBIOLOGY; CATECHOLAMINE; CLONIDINE TEST; APOMORPHINE TEST; MAJOR DEPRESSIVE DISORDER;

D O I：

10.1016/0168-5597(94)00317-8

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The neurobiology of P300 is still a subject of controversy. P300 amplitude appears to be modulated by multiple neurotransmitter systems, especially dopaminergic, noradrenergic as well as cholinergic and GABAergic. In this study, we investigated the relationship between P300 amplitude and catecholaminergic neurotransmission as assessed by the growth hormone (GH) response to clonidine and apomorphine challenges in 20 major depressive patients. Results showed a correlation of P300 amplitude with the apomorphine test (r = 0.54; P = 0.01), but not with the clonidine test (r = 0.22; NS). This study supports a role for dopamine in the neurobiological modulation of P300 amplitude.

引用

页码：194 / 196

页数：3

共 15 条

[1] BLUNTED RESPONSE OF GROWTH-HORMONE TO CLONIDINE AND APOMORPHINE IN ENDOGENOUS-DEPRESSION [J].

ANSSEAU, M ;

VONFRENCKELL, R ;

CERFONTAINE, JL ;

PAPART, P ;

FRANCK, G ;

TIMSITBERTHIER, M ;

GEENEN, V ;

LEGROS, JJ .

BRITISH JOURNAL OF PSYCHIATRY, 1988, 153 :65-71

[2]

CALLAWAY E, 1991, ELECTROEN CLIN NEURO, P173

[3]

Duncan C C, 1987, Electroencephalogr Clin Neurophysiol Suppl, V40, P527

[4] ALTERATIONS IN EVENT-RELATED POTENTIALS (ERPS) OF MPTP-TREATED MONKEYS [J].

GLOVER, A ;

GHILARDI, MF ;

BODISWOLLNER, I ;

ONOFRJ, M .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1988, 71 (06) :461-468

[5]

Halgren E, 1986, FRONTIERS CLIN NEURO, V3, P269

[6] THE P300 EVENT-RELATED POTENTIALS IN DEMENTIA OF THE ALZHEIMER TYPE - CORRELATIONS BETWEEN P300 AND MONOAMINE METABOLITES [J].

ITO, J ;

YAMAO, S ;

FUKUDA, H ;

MIMORI, Y ;

NAKAMURA, S .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1990, 77 (03) :174-178

[7]

KLORMAN R, 1991, ELECTROEN CLIN NEURO, P135

[8] CHOLINERGIC AND SEROTONERGIC EFFECTS ON THE P3 POTENTIAL AND RECENT MEMORY [J].

MEADOR, KJ ;

LORING, DW ;

DAVIS, HC ;

SETHI, KD ;

PATEL, BR ;

ADAMS, RJ ;

HAMMOND, EJ .

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 1989, 11 (02) :252-260

[9] GROWTH-HORMONE RESPONSE TO CLONIDINE AFTER RECOVERY IN PATIENTS WITH ENDOGENOUS-DEPRESSION [J].

MITCHELL, PB ;

BEARN, JA ;

CORN, TH ;

CHECKLEY, SA .

BRITISH JOURNAL OF PSYCHIATRY, 1988, 152 :34-38

[10]

PINEDA JA, 1991, ELECTROEN CLIN NEURO, P165

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