INSIGHTS INTO ERYTHROID-DIFFERENTIATION OBTAINED FROM STUDIES ON AVIAN ERYTHROBLASTOSIS VIRUS

被引:42
作者
BEUG, H
MULLNER, EW
HAYMAN, MJ
机构
[1] INST MOLEC BIOL,VIENNA,AUSTRIA
[2] SUNY STONY BROOK,STONY BROOK,NY 11794
关键词
D O I
10.1016/0955-0674(94)90050-7
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Analysis of the oncogenes v-erbB and v-erbA and their normal proto-oncogene counterparts has revealed several novel aspects of erythroid differentiation. A new erythroid progenitor capable of extended self-renewal has been described, tyrosine kinase receptors and steroid hormone receptors have been found to cooperate in controlling self-renewal, and dramatic alterations in the cell cycle have been found to accompany induction of terminal differentiation.
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页码:816 / 824
页数:9
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