DITHIOCARBAMATE THERAPY FOR NICKEL DERMATITIS

被引：20

作者：

SPRUIT, D

BONGAARTS, PJM

DEJONGH, GJ

机构：

[1] University of Nijmegen, Department of Dermatology, Nijmegen

来源：

CONTACT DERMATITIS | 1978年 / 4卷 / 06期

关键词：

Chelating action; diethyldithiocarbamate; nickel contact dermatitis; scalp hair nickel; urine nickel;

D O I：

10.1111/j.1600-0536.1978.tb03849.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Increased internal exposure to nickel can cause an exacerbation of nickel contact dermatitis. Nickel ions are chelated by diethyldithiocarbamate (DDC) and thereby inactivated. An oral dose of about 1 g DDC/day was given to a patient. The nickel excretion in the urine increased about tenfold; the nickel elimination in scalp hair did not increase. The slightly negative nickel balance did not exhaust the nickel content of the organs appreciably with a dose of 1.2 g DDC/day for 2 months. At the end of this experiment patch tests with nickel sulphate were still positive though less local therapy was needed, and the cross correlation between the activity of the eczema and the nickel concentration in the urine had lost its former periodicity. It is therefore not yet possible to conclude whether or not DDC may be really of help in the very nickel hypersensitive patient by reducing the exposure to nickel originating in food and other environmental sources. Copyright © 1978, Wiley Blackwell. All rights reserved

引用

页码：350 / 358

页数：9

共 20 条

[1]

Christensen B., Moller H., External and internal exposure to the antigen in the hand eczema of nickel allergy, Contact Dermatitis, 1, pp. 136-141, (1975)

[2]

Ellen G., van den Bosch-Tibbesma G., Douma F.F., Nickel content of various Dutch foodstuffs, Zeitschrift für Lehensmittel-Untersuchung und -Forschung, 166, pp. 145-147, (1978)

[3]

Routine patch test series (1974) Recommendations by the International Contact Dermatitis Research Group, British Journal of Dermatology, 89, pp. 437-438, (1973)

[4]

de Jongh G.J., Spruit D., (1978)

[5]

Jongh G.J., de Spruit D., Bongaarts P.J.M., Duller P., (1978)

[6]

Kaaber K., Veien N.K., Tjell J.C., Low nickel diet in the treatment of patients with chronic nickel dermatitis, British Journal of Dermatology, 98, pp. 197-201, (1978)

[7]

Li M., Furst A., Zinc and copper levels in rat hair following nickel administration, Proceedings of the Western Pharmacology Society, 20, pp. 445-448, (1977)

[8]

Malten K.E., Nater J.P., van Ketel W.G., Patch Testing Guidelines, pp. 63-67, (1976)

[9]

Panel on Nickei (1975) Nickel

[10]

Parmeggiani L., Palleni R., Osservazioni sull'impiego del dietilditiocarbammato di sodio in terapia, Medicina Lavoro, 52, pp. 377-381, (1961)

← 1 2 →