DIFFERENTIAL REGULATION OF THE FORMATION OF PROSTAGLANDINS AND RELATED SUBSTANCES FROM ARACHIDONIC-ACID AND FROM DIHOMOGAMMALINOLENIC ACID .2. EFFECTS OF VITAMIN-C

被引:45
作者
MANKU, MS
OKA, M
HORROBIN, DF
机构
[1] Clinical Research Institute, Montreal H2W 1117
来源
PROSTAGLANDINS AND MEDICINE | 1979年 / 3卷 / 02期
关键词
D O I
10.1016/0161-4630(79)90080-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Vitamin C over the concentration range 10 to 100 pg/ml (5.7-57 x 10-5 M) caused a dose dependent and highly significant enhancement of conversion of 14C-dihomogamnalinolenic acid (DGLA) to prostaglandin (PG) El and to thromboxane (Tx) BI by human platelets. Vitamin C had no effect on conversion of 14C-arachidonic acid to PGE2 and TxB2. The concentration range is relevant to physiology: in some cells which concentrate the vitamin, such as polymorphonuclear leucocytes and the adrenal cortex, vitamin C concentrations may be substantially higher than 100 μg/ml. Vitamin C can therefore selectively enhance the formation of cyclo-oxygenase generated products from DGLA without changing formation of those from AA. This effect can account for a number of the known actions of vitamin C including its effect on the immune system. The implications of this finding are discussed. © 1979.
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页码:129 / 137
页数:9
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