2'-C-METHYLSANGIVAMYCINS 3'-C-METHYLSANGIVAMYCINS AND 5'-C-METHYLSANGIVAMYCINS - CONFORMATIONAL LOCK WITH THE METHYL-GROUP

被引：11

作者：

IIMORI, T ^{[1
]}

MURAI, Y ^{[1
]}

OHUCHI, S ^{[1
]}

KODAMA, Y ^{[1
]}

OHTSUKA, Y ^{[1
]}

OISHI, T ^{[1
]}

机构：

[1] MEIJI SEIKA KAISHA LTD, PHARMACEUT RES CTR, KOHOKU KU, YOKOHAMA, KANAGAWA 222, JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 49期

关键词：

D O I：

10.1016/0040-4039(91)80496-S

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Introduction of the methyl groups into the appropriate positions of the ribose moiety in sangivamycin (1) induced the deviation of the conformer population which could be predicted by the molecular mechanics calculations.

引用

页码：7273 / 7276

页数：4

共 18 条

[1] NEW SYNTHESES OF 2'-C-METHYLNUCLEOSIDES STARTING FROM D-GLUCOSE AND D-RIBOSE [J].

BEIGELMAN, LN ;

ERMOLINSKY, BS ;

GURSKAYA, GV ;

TSAPKINA, EN ;

KARPEISKY, MY ;

MIKHAILOV, SN .

CARBOHYDRATE RESEARCH, 1987, 166 (02) :219-232

[2]

CHENG G, 1989, J AM CHEM SOC, V111, P4379

[3] SUBSTRATE PROPERTIES OF CYCLOADENOSINES WITH ADENOSINE AMINOHYDROLASE AS EVIDENCE FOR CONFORMATION OF ENZYME-BOUND ADENOSINE [J].

HAMPTON, A ;

HARPER, PJ ;

SASAKI, T .

BIOCHEMISTRY, 1972, 11 (25) :4736-&

[4]

HORN AS, 1984, XRAY CRYSTALLOGRAPHY, P235

[5] ENANTIOSELECTIVE COMPLEXATION WITH A CONFORMATIONALLY HOMOGENEOUS C2 PODAND IONOPHORE [J].

IIMORI, T ;

ERICKSON, SD ;

RHEINGOLD, AL ;

STILL, WC .

TETRAHEDRON LETTERS, 1989, 30 (50) :6947-6950

[6]

LOOMIS CR, 1988, J BIOL CHEM, V263, P1682

[7] INDUCTION OF MORPHOLOGICAL CHANGE OF HUMAN MYELOID-LEUKEMIA AND ACTIVATION OF PROTEIN-KINASE C BY A NOVEL ANTIBIOTIC, TAUTOMYCIN [J].

MAGAE, J ;

WATANABE, C ;

OSADA, H ;

CHENG, XC ;

ISONO, K .

JOURNAL OF ANTIBIOTICS, 1988, 41 (07) :932-937

[8]

MIKHAILOV SN, 1989, BIOORG KHIM+, V15, P969

[9] SYNTHESIS AND PROPERTIES OF 3'-C-METHYLNUCLEOSIDES AND THEIR PHOSPHORIC ESTERS [J].

MIKHAILOV, SN ;

BEIGELMAN, LN ;

GURSKAYA, GV ;

PADYUKOVA, NS ;

YAKOVLEV, GI ;

KARPEISKY, MY .

CARBOHYDRATE RESEARCH, 1983, 124 (01) :75-96

[10]

MURAI Y, UNPUB HETEROCYCLES

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