THE ANTIBACTERIAL ACTIVITY OF QUINOLONES AGAINST ESCHERICHIA-COLI - A CHEMOMETRIC STUDY

被引：10

作者：

BONELLI, D ^{[1
]}

CECHETTI, V ^{[1
]}

CLEMENTI, S ^{[1
]}

CRUCIANI, G ^{[1
]}

FRAVOLINI, A ^{[1
]}

SAVINO, AF ^{[1
]}

机构：

[1] UNIV PERUGIA,INST PHARMACEUT CHEM & PHARMACEUT TECH,I-06100 PERUGIA,ITALY

来源：

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS | 1991年 / 10卷 / 04期

关键词：

QUINOLONES; CHEMOMETRICS; PARTIAL LEAST SQUARE (PLS); OPTIMIZATION;

D O I：

10.1002/qsar.19910100405

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A chemometric approach based on multivariate calibration and design in latent variables permits one to rationalize the antibacterial activity of quinolones against gram negative bacteria, ranking the relative importance of individual structural features, and suggesting a new active structure.

引用

页码：333 / 343

页数：11

共 41 条

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