QUANTITATIVE LIQUID-CHROMATOGRAPHY, THERMOSPRAY TANDEM MASS-SPECTROMETRY (LC TSP MS MS) ANALYSIS OF SOME THERMOLABILE BENZODIAZEPINES IN WHOLE-BLOOD

被引：29

作者：

VERWEIJ, AMA ^{[1
]}

LIPMAN, PJL ^{[1
]}

ZWEIPFENNING, PGM ^{[1
]}

机构：

[1] MINIST JUSTICE,DEPT GEN CHEM,2288 GD RIJSWIJK,NETHERLANDS

来源：

FORENSIC SCIENCE INTERNATIONAL | 1992年 / 54卷 / 01期

关键词：

BENZODIAZEPINES; WHOLE-BLOOD; QUANTITATIVE ANALYSIS; LC TSP MS MS SRM; DAUGHTER ION MODE;

D O I：

10.1016/0379-0738(92)90081-7

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

An LC/TSP/MS/MS selected reaction monitoring (SRM) method in the daughter ion scan mode can be applied successfully for the quantitative determination of thermolabile benzodiazepines in whole-blood following an Extrelut extraction method. Detection limits as low as 100 pg per injection can be reached for all benzodiazepines. The benzodiazepines under investigation proved to be stable, with the exception of ketazolam for which complete degradation to diazepam was observed.

引用

页码：67 / 74

页数：8

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