EFFECT OF CONDENSED TANNINS AND RELATED-COMPOUNDS ON REVERSE-TRANSCRIPTASE

被引：32

作者：

KAKIUCHI, N ^{[1
]}

KUSUMOTO, IT ^{[1
]}

HATTORI, M ^{[1
]}

NAMBA, T ^{[1
]}

HATANO, T ^{[1
]}

OKUDA, T ^{[1
]}

机构：

[1] OKAYAMA UNIV, FAC PHARMACEUT SCI, OKAYAMA 700, JAPAN

来源：

PHYTOTHERAPY RESEARCH | 1991年 / 5卷 / 06期

关键词：

CONDENSED TANNINS; REVERSE TRANSCRIPTASE INHIBITORS; GALLOYLATED (-)-EPICATECHIN OLIGOMERS;

D O I：

10.1002/ptr.2650050609

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Inhibitory effects of 18 condensed tannins and related compounds on reverse transcriptase from an RNA tumour virus were examined in the presence of poly(riboadenylic acid) oligo(deoxythymidylic acid) ((rA)n(dT)12-18) or poly(ribocytidylic acid) oligo(deoxyguanylic acid) ((rC)n(dG)12-18) as a template-primer. A potent inhibitory effect was found in galloylated monomers and oligomers as well as non-galloylated tetramer, trimer and two of three dimers. The mode of the inhibition of one of them, procyanidin B-2, was competitive with regard to the template-primer.

引用

页码：270 / 272

页数：3

共 15 条

[1] ELLAGITANNIN CONTENT OF LEAVES OF GERANIUM SPECIES [J].