SYNTHESIS OF N-ALPHA-FMOC-N-EPSILON-NVOC-LYSINE AND USE IN THE PREPARATION OF SELECTIVELY FUNCTIONALIZED PEPTIDES

被引：33

作者：

RUSIECKI, VK

WARNE, SA

机构：

[1] Department of Medicinal Chemical Research Merck Research Laboratories, Rahway, NJ 07065-0900

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)81259-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N(alpha)-Fmoc-N(epsilon)-Nvoc-lysine 2 has been prepared and used in the solid phase peptide synthesis (SPPS) of selectively functionalized HIV-1 peptides. The removal of the Nvoc group, from the protected peptide, has been shown to be compatible with the presence of a reactive maleimide linker which is useful for conjugation of peptides to proteins containing thiol groups.

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页码：707 / 710

页数：4

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