VERTICAL TRANSMISSION OF HEPATITIS-C VIRUS (HCV) DETECTED BY HCV-RNA ANALYSIS

被引：15

作者：

KUROKI, T

NISHIGUCHI, S

FUKUDA, K

IKEOKA, N

MURATA, R

ISSHIKI, G

TOMODA, S

OGITA, S

MONNA, T

KOBAYASHI, K

机构：

[1] OSAKA CITY UNIV,SCH MED,DEPT PAEDIAT,ABENO KU,OSAKA 545,JAPAN

[2] OSAKA CITY UNIV,SCH MED,DEPT GYNAECOL,ABENO KU,OSAKA 545,JAPAN

[3] OSAKA CITY UNIV,SCH MED,DEPT PUBL HLTH,ABENO KU,OSAKA 545,JAPAN

来源：

GUT | 1993年 / 34卷 / 02期

关键词：

D O I：

10.1136/gut.34.2_Suppl.S52

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The rate of transmission of hepatitis C virus (HCV) from patients with chronic hepatitis C to their children was studied. Of the 64 children with a parent with chronic hepatitis C, two (3%) had abnormal alanine aminotransferase (ALT) activities, six (9%) had anti-HCV detected by c100 ELISA, seven (11%) had anti-HCV detected by ELISA-II, and 21 (33%) had HCV-RNA by polymerase chain reaction (PCR). Anti-HCV detected by ELISA-II disappeared within six months in all six infants. Of the five children whose mothers were given a blood transfusion after the child's first birthday, none had anti-HCV or HCV-RNA. In the five families whose elder or eldest offspring had HCV-RNA, all of the younger offspring had HCV-RNA. The vertical transmission rate of HCV was low if judged by the presence of anti-HCV or abnormal ALT values, but the rate was high (33%) if judged by the presence of HCV-RNA.

引用

页码：S52 / S53

页数：2

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