COLD ACCLIMATION-RECRUITED NONSHIVERING THERMOGENESIS - THE SYRIAN-HAMSTER IS NOT AN EXCEPTION

被引:19
作者
DICKER, A [1 ]
CANNON, B [1 ]
NEDERGAARD, J [1 ]
机构
[1] UNIV STOCKHOLM, ARRHENIUS LAB F3, WENNER GREN INST, S-10691 STOCKHOLM, SWEDEN
关键词
BROWN ADIPOSE TISSUE; NOREPINEPHRINE; BETA-ADRENERGIC AGENTS; UNCOUPLING PROTEIN; THERMOGENIN;
D O I
10.1152/ajpregu.1995.269.4.R767
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Biochemical evidence from in vitro studies of brown adipose tissue in Syrian hamsters indicates a significant degree of recruitment of the tissue as an effect of cold acclimation. However, earlier in vivo studies indicate a lack of recruitment of nonshivering thermogenesis in the intact animal as a result of cold acclimation. Because of this apparent discrepancy, the occurrence of cold acclimation-recruited nonshivering thermogenesis in hamsters was investigated. Hamsters were cold acclimated to 6 degrees C or remained at 24 degrees C (controls), and their thermogenic response was investigated in an open-circuit system at 24 degrees C. Cold acclimation resulted in a small increase in resting metabolic rate and a major increase in the thermogenic response to norepinephrine (61% increase over resting metabolic rate in controls and 156% increase in cold-acclimated animals). The absolute beta(3)-specific adrenergic agonist CGP-12177 also induced a high rate of nonshivering thermogenesis, which was similarly recruited. It was concluded that, concerning the relative effect of recruitment on the capacity for nonshivering thermogenesis, the intact hamsters responded as would be predicted from in vitro experiments. Thus the hamster does not seem to constitute an exception to the general patterns described for other rodents concerning recruitment of nonshivering thermogenesis due to cold acclimation.
引用
收藏
页码:R767 / R774
页数:8
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