CELL CYCLING AND DNA-REPLICATION IN A MUTANT BLOCKED IN CELL-DIVISION IN NEMATODE CAENORHABDITIS-ELEGANS

被引：69

作者：

ALBERTSON, DG ^{[1
]}

SULSTON, JE ^{[1
]}

WHITE, JG ^{[1
]}

机构：

[1] MRC, MOLEC BIOL LAB, CAMBRIDGE CB2 2QH, ENGLAND

来源：

DEVELOPMENTAL BIOLOGY | 1978年 / 63卷 / 01期

关键词：

D O I：

10.1016/0012-1606(78)90122-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The postembryonic development of the nematode C. elegans was described at the level of individual cell lineages. A mutant of postembryonic development, lin-5 II, caused a failure of postembryonic nuclear and cell divisions. Mitosis in living animals was seen by light microscopy to proceed through prophase and nuclear breakdown, but an abnormal-looking metaphase plate formed in the mutant, after which the interphase nuclear morphology reappeared until the next attempted round of division. The precursor cells which gave rise to theventral nerve cord were studied in lin-5. In the wild type these cells divided asymmetrically to give 6 descendants (1 hypodermal cell and 5 neurons). In the mutant these precursors accumulated approximately 6 times the diploid quantity of DNA within a single nucleus, while attempting mitosis up to 3 times. These polyploid cells displayed characteristics of the cells they would have produced ordinarily.

引用

页码：165 / 178

页数：14

共 18 条

[1]

BRENNER S, 1974, GENETICS, V77, P71

[2] MUTATION SELECTION AND NATURAL-HISTORY OF CANCER [J].