PRODUCTION OF SUPEROXIDE ANION RADICALS IN REACTION OF REDUCED FLAVINS AND FLAVOPROTEINS WITH MOLECULAR OXYGEN

被引：398

作者：

MASSEY, V

STRICKLAND, S

MAYHEW, SG

HOWELL, LG

ENGEL, PC

MATTHEWS, RG

SCHUMAN, M

SULLIVAN, PA

机构：

[1] Department of Biological Chemistry, University of Michigan, Ann Arbor

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 36卷 / 06期

关键词：

D O I：

10.1016/0006-291X(69)90287-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The generation of O2•- in the reaction of reduced flavins and several flavoproteins has been shown. This has been demonstrated by the ability to catalyse the aerobic reduction of cytochrome c and the inhibition of this reduction by erythrocuprein. In contrast to the results with the intact enzyme, the reduction of cytochrome c by deflavoxanthine oxidase is not inhibited by erythrocuprein, indicating that the site of production of O2•- in the native enzyme is flavin, rather than non-heme iron. © 1969.

引用

页码：891 / +

页数：1

共 27 条

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