Location of Facioscapulohumeral muscular dystrophy gene on chromosome 4

被引：263

作者：

Wijmenga, C

Frants, RR

Browwer, OF

Moerer, P

Weber, JL

Padberg, GW

机构：

[1] Leiden Univ, Dept Neurol, Leiden, NETHERLANDS

[2] Leiden Univ, Dept Human Genet, Leiden, NETHERLANDS

[3] Marshfield Med Res Fdn, Marshfield, WI USA

来源：

LANCET | 1990年 / 336卷 / 8716期

关键词：

D O I：

10.1016/0140-6736(90)92148-B

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The autosomal dominant disorder facioscapulohumeral muscular dystrophy (FSHD) is the last of the major progressive muscular dystrophies in which the gene had not been located. In linkage analysis on ten Dutch families with this disorder a lod score of 6·34 at a recombination fraction of 0·13 was obtained with the microsatellite marker Mfd 22 (D4S171). This maps the FSHD gene to chromsome 4. Only one family was uninformative for this marker. We found no evidence of genetic heterogeneity. © 1990.

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页码：651 / 653

页数：3

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