MODULATION OF INTERLEUKIN-1-BETA PRODUCTION BY CYCLIC-AMP IN HUMAN MONOCYTES

被引：57

作者：

HURME, M

机构：

[1] Department of Bacteriology and Immunology, University of Helsinki, 00290 Helsinki

来源：

FEBS LETTERS | 1990年 / 263卷 / 01期

基金：

芬兰科学院;

关键词：

(Human); AMP; 3'; 5'-cyclic; Interieukin-1; Monocyte;

D O I：

10.1016/0014-5793(90)80699-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Elevation of cAMP has been considered to be an important downregulative signal in the production ofinterieukin-1(IL-1). This study demonstrates that this phenomenon is dependent on the signal used to activate the IL-1 production. The IL-1β production of lipopolysaccharide activated human monocytes was readily inhibited by dibutyryl cAMP. This took place without a significant change in the steady-state levels of IL-1β mRNA. By contrast, in PMA activated monocytes 100 μM dibutyryl cAMP increased in IL-1β production ca. 4-fold. The steady-statelevels of IL-1β mRNA were also simultaneously increased. © 1990.

引用

页码：35 / 37

页数：3

共 18 条

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