EFFECT OF ALPHA-2-MACROGLOBULIN ON CYTOKINE-MEDIATED HUMAN C-REACTIVE PROTEIN-PRODUCTION

被引：10

作者：

TAYLOR, AW ^{[1
]}

MORTENSEN, RF ^{[1
]}

机构：

[1] OHIO STATE UNIV,CTR COMPREHENS CANC,COLUMBUS,OH 43210

来源：

INFLAMMATION | 1991年 / 15卷 / 01期

关键词：

D O I：

10.1007/BF00917910

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alpha-2-macroglobulin (alpha-2-M), a serum protease inhibitor that also binds cytokines, neutralized the inhibitory effect exerted by transforming growth factor-beta (TGF-beta) on IL-6-induced C-reactive protein (CRP) production by the human hepatoma cell line PLC/PRF/5. alpha-2-M was found to bind noncovalently with TGF-beta to form a complex that, upon acidification, released TGF-beta inhibitory activity as detected by IL-6-induced CRP production. Although alpha-2-M also binds IL-6, it did not alter IL-6-induced CRP production by the hepatoma cells. The interaction between alpha-2-M and TGF-beta may influence the production of acute-phase proteins by liver hepatocytes.

引用

页码：61 / 70

页数：10

共 34 条

[1] CONTROLLED SYNTHESIS OF HBSAG IN A DIFFERENTIATED HUMAN-LIVER CARCINOMA-DERIVED CELL-LINE [J].

ADEN, DP ;

FOGEL, A ;

PLOTKIN, S ;

DAMJANOV, I ;

KNOWLES, BB .

NATURE, 1979, 282 (5739) :615-616

[2]

ARAKAWA H, 1989, J BIOL CHEM, V264, P2350

[3] THE CYTOKINE NETWORK [J].

BALKWILL, FR ;

BURKE, F .

IMMUNOLOGY TODAY, 1989, 10 (09) :299-303

[4]

BAUMANN H, 1989, IN VITRO CELL DEV B, V25, P115

[5]

BORTH W, 1988, J BIOL CHEM, V264, P5518

[6]

CASTELL JV, 1989, ANN NY ACAD SCI, V557, P87

[7]

DANIELPOUR D, 1990, J BIOL CHEM, V265, P6973

[8] MONOCYTE-CONDITIONED MEDIUM, INTERLEUKIN-1, AND TUMOR-NECROSIS-FACTOR STIMULATE THE ACUTE PHASE RESPONSE IN HUMAN HEPATOMA-CELLS INVITRO [J].

DARLINGTON, GJ ;

WILSON, DR ;

LACHMAN, LB .

JOURNAL OF CELL BIOLOGY, 1986, 103 (03) :787-793

[9]

DEBANNE MT, 1976, BIOCHIM BIOPHYS ACTA, V428, P466

[10] HUMAN TRANSFORMING GROWTH FACTOR-BETA COMPLEMENTARY-DNA SEQUENCE AND EXPRESSION IN NORMAL AND TRANSFORMED-CELLS [J].

DERYNCK, R ;

JARRETT, JA ;

CHEN, EY ;

EATON, DH ;

BELL, JR ;

ASSOIAN, RK ;

ROBERTS, AB ;

SPORN, MB ;

GOEDDEL, DV .

NATURE, 1985, 316 (6030) :701-705

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