THE EFFECTS OF DISCRETE GAP JUNCTION COUPLING ON PROPAGATION IN MYOCARDIUM

被引：163

作者：

KEENER, JP

机构：

[1] Department of Mathematics, University of Utah, Salt Lake City

来源：

JOURNAL OF THEORETICAL BIOLOGY | 1991年 / 148卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0022-5193(05)80465-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A modified cable theory for a bi-domain model of myocardium that incorporates the effect of gap junctions as discrete objects coupling cardiac cells is derived. The theory is shown to be in agreement with a number of experiments that cannot be explained using standard continuous cable theory, and resolves some apparent contradictions on failure of propagation in two-dimensional anisotropic tissue. In addition, some as yet untested predictions of the theory are mentioned. © 1991 Academic Press Limited.

引用

页码：49 / 82

页数：34

共 42 条

[1] EFFECTS OF CELLULAR UNCOUPLING ON CONDUCTION IN ANISOTROPIC CANINE VENTRICULAR MYOCARDIUM
BALKE, CW
LESH, MD
SPEAR, JF
KADISH, A
LEVINE, JH
MOORE, EN
[J]. CIRCULATION RESEARCH, 1988, 63 (05) : 879 - 892
[2] RECONSTRUCTION OF ACTION POTENTIAL OF VENTRICULAR MYOCARDIAL FIBERS
BEELER, GW
REUTER, H
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1977, 268 (01): : 177 - 210
[3] DIRECTIONAL DIFFERENCES OF IMPULSE SPREAD IN TRABECULAR MUSCLE FROM MAMMALIAN HEART
CLERC, L
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1976, 255 (02): : 335 - 346
[4] GAP JUNCTION UNCOUPLING AND DISCONTINUOUS PROPAGATION IN THE HEART - A COMPARISON OF EXPERIMENTAL-DATA WITH COMPUTER-SIMULATIONS
COLE, WC
PICONE, JB
SPERELAKIS, N
[J]. BIOPHYSICAL JOURNAL, 1988, 53 (05) : 809 - 818
[5] DIRECTIONAL DIFFERENCES IN EXCITABILITY AND MARGIN OF SAFETY FOR PROPAGATION IN SHEEP VENTRICULAR EPICARDIAL MUSCLE
DELGADO, C
STEINHAUS, B
DELMAR, M
CHIALVO, DR
JALIFE, J
[J]. CIRCULATION RESEARCH, 1990, 67 (01) : 97 - 110
[6] EFFECTS OF INCREASING INTERCELLULAR RESISTANCE ON TRANSVERSE AND LONGITUDINAL PROPAGATION IN SHEEP EPICARDIAL MUSCLE
DELMAR, M
MICHAELS, DC
JOHNSON, T
JALIFE, J
[J]. CIRCULATION RESEARCH, 1987, 60 (05) : 780 - 785
[7] INTERCALATED DISKS AS A CAUSE FOR DISCONTINUOUS PROPAGATION IN CARDIAC-MUSCLE - A THEORETICAL SIMULATION
DIAZ, PJ
RUDY, Y
PLONSEY, R
[J]. ANNALS OF BIOMEDICAL ENGINEERING, 1983, 11 (3-4) : 177 - 189
[8] FAST SODIUM CURRENT IN CARDIAC-MUSCLE - A QUANTITATIVE DESCRIPTION
EBIHARA, L
JOHNSON, EA
[J]. BIOPHYSICAL JOURNAL, 1980, 32 (02) : 779 - 790
[9] FIFE PC, 1979, LECTURE NOTES BIOMAT
[10] CHANGES OF ACTION POTENTIAL SHAPE AND VELOCITY FOR CHANGING CORE CONDUCTOR GEOMETRY
GOLDSTEIN, SS
RALL, W
[J]. BIOPHYSICAL JOURNAL, 1974, 14 (10) : 731 - 757

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