CRYSTAL-STRUCTURE OF ARTEMISINIC ACID - A POSSIBLE BIOGENETIC PRECURSOR OF ANTIMALARIAL ARTEMISININ FROM ARTEMISIA-ANNUA

被引：33

作者：

MISRA, LN ^{[1
]}

AHMAD, A ^{[1
]}

THAKUR, RS ^{[1
]}

LOTTER, H ^{[1
]}

WAGNER, H ^{[1
]}

机构：

[1] INST PHARMACEUT BIOL, W-8000 MUNICH 2, GERMANY

来源：

JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 02期

关键词：

D O I：

10.1021/np50092a005

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Artemisinic acid [1), a possible biogenetic precursor of the antimalarial artemisinin [2], was isolated from the hexane extract of Artemisia annua. X-ray crystallography of the dimer of artemisinic acid shows that the cyclization during intermolecular hydrogen bonding occurs by the opposite orientation of the alpha,beta-methylene group in each molecule. Complete spectroscopic data of 1 are also given.

引用

页码：215 / 219

页数：5

共 7 条

[1] ON THE POSSIBLE ROLE OF QUINGHAO ACID IN THE BIOSYNTHESIS OF ARTEMISININ [J].