IMINOHEPTITOLS AS GLYCOSIDASE INHIBITORS - SYNTHESIS OF ALPHA-HOMOMANNOJIRIMYCIN, 6-EPI-ALPHA-HOMOMANNOJIRIMYCIN AND OF A HIGHLY SUBSTITUTED PIPECOLIC ACID

被引：71

作者：

BRUCE, I

FLEET, GWJ

DIBELLO, IC

WINCHESTER, B

机构：

[1] UNIV OXFORD,DYSON PERRINS LAB,S PARKS RD,OXFORD OX1 3QY,ENGLAND

[2] UNIV LONDON,INST CHILD HLTH,DIV BIOCHEM & METAB,LONDON WC1N 1EH,ENGLAND

来源：

TETRAHEDRON | 1992年 / 48卷 / 46期

关键词：

D O I：

10.1016/S0040-4020(01)89047-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In a search for a mannopyranose analogue which inhibits alpha-mannosidases but not alpha-fucosidases, alpha-homonojirimycin was prepared; the syntheses of 6-epi-alpha-homonojirimycin and of 2,6-dideoxy-2,6-imino-L-glycero-D-talo-heptonic acid (a highly substituted pipecolic acid) are also reported.

引用

页码：10191 / 10200

页数：10

共 32 条

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