CHARACTERIZATION OF 2 NOVEL CASEIN TRANSCRIPTS IN RABBIT MAMMARY-GLAND

被引：11

作者：

DAWSON, SP

WILDE, CJ

TIGHE, PJ

MAYER, RJ

机构：

[1] HANNAH RES INST,DIRECTORS GRP,AYR KA6 5HL,SCOTLAND

[2] UNIV NOTTINGHAM,QUEENS MED CTR,DEPT IMMUNOL,NOTTINGHAM NG7 2UH,ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1993年 / 296卷

关键词：

D O I：

10.1042/bj2960777

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two clones were isolated from a cDNA library corresponding to mRNAs which accumulate in mid-lactating (14 day) rabbit mammary gland and characterized by DNA sequencing. The two clones sequenced corresponded to two novel casein transcripts (pBRM5 and pBRM42). Relative mRNA abundances for the two clones were assessed by dot-blot analysis. Phylogenetic analysis and comparison of both pBRM5 and pBRM42 with other members of the casein family revealed that the rabbit may be unique among mammals in expressing two alpha(s2)-casein genes. The presence of two alpha(s2)-casein genes in the rabbit may be the result of a relatively recent intergenic duplication event.

引用

收藏

页码：777 / 784

页数：8

相关论文

共 31 条

[1] RAT BETA-CASEIN CDNA - SEQUENCE-ANALYSIS AND EVOLUTIONARY COMPARISONS [J].

BLACKBURN, DE ;

HOBBS, AA ;

ROSEN, JM .

NUCLEIC ACIDS RESEARCH, 1982, 10 (07) :2295-2307

[2] RECENT STUDIES ON NUCLEOTIDE-SEQUENCES ENCODING THE CASEINS [J].

BONSING, J ;

MACKINLAY, AG .

JOURNAL OF DAIRY RESEARCH, 1987, 54 (03) :447-461

[3] COMPLETE AMINO-ACID SEQUENCE OF BOVINE ALPHA-S2-CASEIN [J].

BRIGNON, G ;

RIBADEAUDUMAS, B ;

MERCIER, JC ;

PELISSIER, JP ;

DAS, BC .

FEBS LETTERS, 1977, 76 (02) :274-279

[4] TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL ROLES OF GLUCOCORTICOID IN THE EXPRESSION OF THE RAT 25,000 MOLECULAR-WEIGHT CASEIN GENE [J].

CHOMCZYNSKI, P ;

QASBA, P ;

TOPPER, YJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 134 (02) :812-818

[5]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[6]

Dayhoff M. O., 1972, ATLAS PROTEIN SEQUEN, V5, P89

[7] PROLACTIN AND GLUCOCORTICOID HORMONES SYNERGISTICALLY INDUCE EXPRESSION OF TRANSFECTED RAT BETA-CASEIN GENE PROMOTER CONSTRUCTS IN A MAMMARY EPITHELIAL-CELL LINE [J].

DOPPLER, W ;

GRONER, B ;

BALL, RK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (01) :104-108

[8]

EISENSTEIN RS, 1988, MOL CELL BIOL, V39, P783

[9]

FELSENSTEIN J, 1985, EVOLUTION, V39, P783, DOI 10.1111/j.1558-5646.1985.tb00420.x

[10] GUINEA-PIG CASEIN-A CDNA - NUCLEOTIDE-SEQUENCE ANALYSIS AND COMPARISON OF THE DEDUCED PROTEIN-SEQUENCE WITH THAT OF BOVINE ALPHA-S2 CASEIN [J].

HALL, L ;

LAIRD, JE ;

PASCALL, JC ;

CRAIG, RK .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1984, 138 (03) :585-589

← 1 2 3 4 →