EVIDENCE FOR THE PHAGOCYTOSIS OF INTACT OLIGOLAMELLAR LIPOSOMES BY HUMAN KERATINOCYTES INVITRO AND CONSECUTIVE INTRACELLULAR DISINTEGRATION

被引：16

作者：

KORTING, HC

SCHMID, MH

HARTINGER, A

MAIERHOFER, G

STOLZ, W

BRAUNFALCO, O

机构：

[1] Department of Dermatology, Ludwig-Maximilians-University, D(W)-8000, München, Frauenlobstr.

[2] Department of Microbiology, Städtisches Krankenhaus München-Bogenhausen, D(W)-8000, München, Englschalkinger Str.

[3] Dianorm Company, Stöcklstr, D(W)-8000, München

来源：

JOURNAL OF MICROENCAPSULATION | 1993年 / 10卷 / 02期

关键词：

D O I：

10.3109/02652049309104388

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

While there is evidence for the use of liposomes as drug carriers upon topical application to the skin, the underlying mechanisms are far from being clear. Therefore human keratinocytes grown in vitro were exposed to large oligolamellar liposomes. After attachment and invagination these particles can be found unchanged within the cytoplasm both inside and outside of lysosomes. If incorporated into lysosomes the structural lipids can be disintegrated and spread within the entire phagolysosome. Gold labeling adds further to the hypothesis of intact uptake of liposomes by the living cells of the human epidermis.

引用

页码：223 / 228

页数：6

共 14 条

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