NUCLEOTIDE RECEPTORS ON DDT1 MF-2 VAS-DEFERENS CELLS

被引：9

作者：

VANDERZEE, L ^{[1
]}

NELEMANS, A ^{[1
]}

DENHERTOG, A ^{[1
]}

机构：

[1] UNIV GRONINGEN,DEPT PHARMACOL CLIN PHARMACOL,BLOEMSINGEL 1,9713 BZ GRONINGEN,NETHERLANDS

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 215卷 / 2-3期

关键词：

SMOOTH MUSCLE CELLS; DDT1; MF-2; CELLS; NUCLEOTIDE RECEPTORS; ATP; UTP; K+ CURRENTS;

D O I：

10.1016/0014-2999(92)90048-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

On exposure to triphosphatic nucleotides vas deferens DDT1 MF-2 smooth muscle cells responded with an outward K+ current as measured with the whole-cell patch clamp configuration. The rank order of potency was: ATP > UTP > TTP > CTP = GTP. The responses evoked by these agonists were blocked by suramin. Adenosine, ADP, alpha,beta-methylene-ATP and 2-methylthio-ATP did not affect the transmembrane current. The responses evoked by the nucleotides in DDT1 MF-2 cells are supposed to be mediated via 'nucleotide' receptors.

引用

页码：317 / 320

页数：4

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