INTERACTION OF DOUBLE-HELICAL POLYNUCLEAR COPPER(I) COMPLEXES WITH DOUBLE-STRANDED DNA

被引:77
作者
SCHOENTJES, B [1 ]
LEHN, JM [1 ]
机构
[1] UNIV STRASBOURG 1,CHIM SUPRAMOLEC LAB,CNRS,URA 422,F-67000 STRASBOURG,FRANCE
关键词
D O I
10.1002/hlca.19950780103
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Double-helical metal complexes, the helicates H-2-H-5, were found to bind to double-helical DNA by spectroscopic, DNA-melting, and electrophoretic-mobility measurements. The helicates also inhibited the cleavage of DNA by two restriction enzymes, SspI and EcoRV, a property which agrees with the binding occurring in the major groove of the double helix. Visible-light irradiation of solutions containing a helicate and the pBR322 plasmid led to single-strand cleavage, indicating that these complexes could be of interest as potential probes for nucleic-acid structure.
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页码:1 / 12
页数:12
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