INVIVO METABOLISM AND KINETICS OF TC-99M-HMPAO

被引：26

作者：

LUCIGNANI, G ^{[1
]}

ROSSETTI, C ^{[1
]}

FERRARIO, P ^{[1
]}

ZECCA, L ^{[1
]}

GILARDI, MC ^{[1
]}

ZITO, F ^{[1
]}

PERANI, D ^{[1
]}

LENZI, GL ^{[1
]}

FAZIO, F ^{[1
]}

机构：

[1] UNIV ROME, DIPARTIMENTO SCI NEUROL, I-00100 ROME, ITALY

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1990年 / 16卷 / 4-6期

关键词：

!sup]99m[!/sup]Tc; Blood flow; Brain; SPECT;

D O I：

10.1007/BF00842776

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The cerebral distribution of99mTc-labeled d, l, hexamethyl-propylene-amine-oxime (99mTc-HMPAO) as a function of rCBF and time was examined in rats and in man. The results of this study confirm that99mTc-HMPAO is distributed in brain in proportion to rCBF. However, the rapid systemic breakdown of the tracer in blood results in considerable difficulties in the assessment of the arterial concentration of the parent compound; incomplete extraction of99mTc-HMPAO from blood to brain and significant efflux from brain represent further limitations in the use of this tracer for quantification of rCFB. Despite these limitations99mTc-HMPAO is of potential interest for a qualitative assessment of rCBF in specific clinical conditions. © 1990 Springer-Verlag.

引用

页码：249 / 255

页数：7

共 15 条

[1] ASSESSMENT OF THE ARTERIAL INPUT CURVE FOR [TC-99M] D,L-HM-PAO BY RAPID OCTANOL EXTRACTION [J].

ANDERSEN, AR ;

FRIBERG, H ;

LASSEN, NA ;

KRISTENSEN, K ;

NEIRINCKX, RD .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1988, 8 (06) :S23-S30

[2] COMPENSATION OF TISSUE ABSORPTION IN EMISSION TOMOGRAPHY [J].

BELLINI, S ;

PIACENTINI, M ;

CAFFORIO, C ;

ROCCA, F .

IEEE TRANSACTIONS ON ACOUSTICS SPEECH AND SIGNAL PROCESSING, 1979, 27 (03) :213-218

[3]

KUHL DE, 1982, J NUCL MED, V23, P196

[4]

KUNG HF, 1980, J NUCL MED, V21, P147

[5] THE RETENTION OF [TC-99M] D,L-HM-PAO IN THE HUMAN-BRAIN AFTER INTRACAROTID BOLUS INJECTION - A KINETIC-ANALYSIS [J].

LASSEN, NA ;

ANDERSEN, AR ;

FRIBERG, L ;

PAULSON, OB .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1988, 8 (06) :S13-S22

[6]

LEAR JL, 1988, J NUCL MED, V29, P1387

[7] INITIAL CEREBRAL HM-PAO DISTRIBUTION COMPARED TO LCBF - USE OF A MODEL WHICH CONSIDERS CEREBRAL HM-PAO TRAPPING KINETICS [J].

LEAR, JL .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1988, 8 (06) :S31-S37

[8] METABOLIC AND KINETIC CONSIDERATIONS IN THE USE OF [I-125] HIPDM FOR QUANTITATIVE MEASUREMENT OF REGIONAL CEREBRAL BLOOD-FLOW [J].

LUCIGNANI, G ;

NEHLIG, A ;

BLASBERG, R ;

PATLAK, CS ;

ANDERSON, L ;

FIESCHI, C ;

FAZIO, F ;

SOKOLOFF, L .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1985, 5 (01) :86-96

[9] DETERMINATION OF FLOW AND RATE CONSTANTS IN A KINETIC-MODEL OF [TC-99M] HEXAMETHYL-PROPYLENE AMINE OXIME IN THE HUMAN-BRAIN [J].

MATSUDA, H ;

OBA, H ;

SEKI, H ;

HIGASHI, S ;

SUMIYA, H ;

TSUJI, S ;

TERADA, H ;

IMAI, K ;

SHIBA, K ;

MORI, H ;

HISADA, K .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1988, 8 (06) :S61-S68

[10]

NEIRINCKX RD, 1987, J NUCL MED, V28, P191

← 1 2 →