SYNTHESIS OF 2,2-DIALKYL-3-HALOPROPANENITRILES FROM 2,2-DIALKYLETHANENITRILES AND DIHALOMETHANES

被引：3

作者：

CLIFFE, IA

TODD, RS

WHITE, AC

机构：

[1] Department of Medicinal Chemistry, Wyeth Research, (U.K.), Huntercombe Lane South, Taplow, Maidenhead

来源：

SYNTHETIC COMMUNICATIONS | 1990年 / 20卷 / 12期

关键词：

D O I：

10.1080/00397919008053100

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

: A simple high-yielding synthesis of 2,2- dialkyl-3-halopropanenitriles is described which involves the alkylation of 2,2-dialkylethanenitriles with bromochloromethane. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：1757 / 1767

页数：11

共 18 条

[1]

Arseniyadis S., 1984, ORG REACT, V31, P1, DOI DOI 10.1002/0471264180.OR031.01

[2] ALIPHATIC CHEMISTRY OF FLUORENE .9. SOME BIFUNCTIONAL DERIVATIVES [J].

BAVIN, PMG .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1964, 42 (06) :1409-&

[3] ORGANOBORANES .46. NEW PROCEDURES FOR THE HOMOLOGATION OF BORONIC ESTERS - A CRITICAL-EXAMINATION OF THE AVAILABLE PROCEDURES TO ACHIEVE CONVENIENT HOMOLOGATION OF BORONIC ESTERS [J].

BROWN, HC ;

SINGH, SM ;

RANGAISHENVI, MV .

JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (16) :3150-3155

[4]

CASS OW, 1947, Patent No. 2425029

[5]

CLIFFE IA, UNPUB

[6]

DECOMBE J, 1965, CR HEBD ACAD SCI, V260, P6628

[7] SYNTHESIS OF COMPOUNDS FOR CHEMOTHERAPY OF TUBERCULOSIS .7. PYRIDINE N-OXIDES WITH SULFUR-CONTAINING GROUPS [J].

GARDNER, TS ;

WENIS, E ;

LEE, J .

JOURNAL OF ORGANIC CHEMISTRY, 1957, 22 (08) :984-986

[8]

Ho T.L., 1977, HARD SOFT ACIDS BASE

[9] CHEMISTRY OF STABLE ALPHA-HALOGENOORGANOLITHIUM COMPOUNDS AND MECHANISM OF CARBENOID REACTIONS [J].

KOBRICH, G .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1967, 6 (01) :41-&

[10] ESTER HOMOLOGATION VIA ALPHA-BROMO-ALPHA-KETO DIANION REARRANGEMENT [J].

KOWALSKI, CJ ;

HAQUE, MS ;

FIELDS, KW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (05) :1429-1430

← 1 2 →