NUCLEAR RECEPTOR THAT IDENTIFIES A NOVEL RETINOIC ACID RESPONSE PATHWAY

被引：1483

作者：

MANGELSDORF, DJ ^{[1
]}

ONG, ES ^{[1
]}

DYCK, JA ^{[1
]}

EVANS, RM ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,SCH MED,PHYSIOL & PHARMACOL PROGRAM,LA JOLLA,CA 92093

来源：

NATURE | 1990年 / 345卷 / 6272期

关键词：

D O I：

10.1038/345224a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Molecular cloning and transcriptional activation studies have revealed a new protein similar to the steroid hormone receptors and which responds specifically to vitamin A metabolites. This protein is substantially different in primary structure and ligand specificity from the products of the previously described retinoic acid receptor gene family. By indicating the existence of an additional pathway through which retinoic acid may exert its effects, these data lead to a re-evaluation of retinoid physiology. © 1990 Nature Publishing Group.

引用

页码：224 / 229

页数：6

共 50 条

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