MAGNESIUM DEFICIENCY-INDUCED CARDIOMYOPATHY - PROTECTION BY VITAMIN-E

被引：72

作者：

FREEDMAN, AM ^{[1
]}

ATRAKCHI, AH ^{[1
]}

CASSIDY, MM ^{[1
]}

WEGLICKI, WB ^{[1
]}

机构：

[1] GEORGE WASHINGTON UNIV,MED CTR,DEPT PHYSIOL,WASHINGTON,DC 20037

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 170卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)90506-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Syrian male hamsters weighing 80-100g were placed on either a magnesium deficient diet (MgD) or an identical diet supplemented with 100 mmols/Kg MgCl. Animals from each group received vitamin E 10, 15, and 25mg three-week slow release pellets, as subcutaneous implants. The animals were sacrificed after 14 days and their hearts isolated for morphological analysis. H&E stained sections were examined by a computer image analysis system for a morphometric determination of the severity of myocardial injury. Vitamin E significantly (p<0.01) reduced both the numerical density and the area fraction of MgD lesions. These data indicate possible free radical participation in the mechanism of injury. © 1990.

引用

页码：1102 / 1106

页数：5

共 18 条

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