PLACENTAL BED SPIRAL ARTERIES IN THE HYPERTENSIVE DISORDERS OF PREGNANCY

被引:538
作者
PIJNENBORG, R
ANTHONY, J
DAVEY, DA
REES, A
TILTMAN, A
VERCRUYSSE, L
VANASSCHE, A
机构
[1] UNIV CAPE TOWN,DEPT OBSTET & GYNAECOL,CAPE TOWN,SOUTH AFRICA
[2] UNIV CAPE TOWN,DEPT PATHOL,CAPE TOWN,SOUTH AFRICA
[3] CATHOLIC UNIV LEUVEN,DEPT OBSTET & GYNAECOL,B-3000 LOUVAIN,BELGIUM
来源
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 1991年 / 98卷 / 07期
关键词
D O I
10.1111/j.1471-0528.1991.tb13450.x
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective - The investigation of the histology of the placental bed spiral arteries in normal pregnancy and in pregnancies complicated by hypertension, with or without proteinura. Design - An observational study, based on women having caesarean sections for clinical reasons. Subjects - 17 normal pregnant women, 43 with gestational hypertension, of whom 39 had proteinuria, 17 with chronic hypertension, of whom 6 had proteinuria, and 5 with unclassified hypertension. Interventions - Placental bed biopsies obtained during caesarean section. Main outcome measures - Histological appearance of sections stained with haematoxylin and eosin PAS and Lendrum's MSB. Results - Biopsies containing spiral arteries were obtained from 6 normotensive and 44 hypertensive women. Trophoblastic invasion was present in 5 of the 6 normotensive biopsies but absent in the majority of those with hypertension. Subintimal proliferation was seen in all the normotensive biopsies but in only 8 of 28 from those with gestational hypertension and proteinuria. Other features seen predominantly or only in the hypertensive biopsies, in order of frequency, were medial hyperplasia, fibrin deposits, acute atherosis, endothelial vacuolation and thrombosis. Conclusion - Absence of physiological changes may not be peculiar to pre-eclampsia but may be associated or even a result of various forms of hypertension in pregnancy. Spiral arteries show a spectrum of changes in hypertensive pregnancies that do not appear to bear a clear-cut relation to the clinical signs.
引用
收藏
页码:648 / 655
页数:8
相关论文
共 19 条
  • [1] PHYSIOLOGICAL RESPONSE OF VESSELS OF PLACENTAL BED TO NORMAL PREGNANCY
    BROSENS, I
    ROBERTSON, WB
    DIXON, HG
    [J]. JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1967, 93 (02): : 569 - +
  • [2] BROSENS I, 1977, BRIT J OBSTET GYNAEC, V84, P656
  • [3] Brosens I A, 1972, Obstet Gynecol Annu, V1, P177
  • [4] BROSENS IA, 1977, CLIN OBSTET GYNAECOL, V4, P573
  • [5] BROWNE JCM, 1953, J OBSTET GYN BRIT EM, V60, P141
  • [6] THE CLASSIFICATION AND DEFINITION OF THE HYPERTENSIVE DISORDERS OF PREGNANCY
    DAVEY, DA
    MACGILLIVRAY, I
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1988, 158 (04) : 892 - 898
  • [7] THE HUMAN PLACENTAL BED - ELECTRON-MICROSCOPIC STUDY OF TROPHOBLASTIC INVASION OF SPIRAL ARTERIES
    DEWOLF, F
    DEWOLFPEETERS, C
    BROSENS, I
    ROBERTSON, WB
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1980, 137 (01) : 58 - 70
  • [8] FOX H, 1978, PATHOLOGY PLACENTA, P75
  • [9] HISTOLOGICAL FEATURES OF UTEROPLACENTAL VESSELS IN NORMAL AND HYPERTENSIVE PATIENTS IN RELATION TO BIRTH-WEIGHT
    FRUSCA, T
    MORASSI, L
    PECORELLI, S
    GRIGOLATO, P
    GASTALDI, A
    [J]. BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1989, 96 (07): : 835 - 839
  • [10] TROPHOBLAST ALTERATIONS IN THE PLACENTAL BED IN RELATION TO PHYSIOLOGICAL-CHANGES IN SPIRAL ARTERIES
    GERRETSEN, G
    HUISJES, HJ
    HARDONK, MJ
    ELEMA, JD
    [J]. BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1983, 90 (01): : 34 - 39