CYTOSTATIC EFFECTS OF DOLASTATIN-10 AND DOLASTATIN-15 ON HUMAN LEUKEMIA-CELL LINES

被引：21

作者：

QUENTMEIER, H

BRAUER, S

PETTIT, GR

DREXLER, HG

机构：

[1] Deutsche Sammlung von Mikroorganismen und Zellkulturen, Braunschweig

[2] Department of Chemistry, Cancer Research Institute, Arizona State University, Tempe, AZ

来源：

LEUKEMIA & LYMPHOMA | 1992年 / 6卷 / 03期

关键词：

DOLASTATIN; LEUKEMIA; CELL LINES; CYTOSTATIC;

D O I：

10.3109/10428199209064902

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We studied in vitro the cytostatic/cytotoxic effects of the peptides dolastatin 10 and dolastatin 15 on various human leukemia cell lines, peripheral blood mononuclear cells (PBMNC), and tonsillar mononuclear cells (tonsillar MNC). On leukemia cell lines both drugs proved to be highly potent cvtostatic agents; however, the cells were not killed even at concentrations of maximum growth-inhibition. Growth-suppression was not paralleled by induced differentiation as exposure to dolastatins did not significantly alter the immunophenotype, cytochemistry or morphology of HL-60 cells. Growth-inhibitory effects of dolastatins were reversed following the removal of the agents from the culture medium. The dolastatins inhibited proliferation of leukemia cell lines at lower concentrations than those which inhibited the growth of stimulated tonsillar MNC. The growth-inhibiting properties of the dolastatins regarding leukemia cell lines and their low toxicity towards normal MNC indicate that these agents might be promising new drugs for future experiments examining their effects on primary leukemic cells. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：245 / 250

页数：6

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