PROTON ASSISTED INTRAMOLECULAR ELECTRON-TRANSFER REACTIONS IN DNA - A PROPOSED MECHANISM

被引：16

作者：

FARAGGI, M ^{[1
]}

KLAPPER, MH ^{[1
]}

机构：

[1] OHIO STATE UNIV,DEPT CHEM,COLUMBUS,OH 43210

来源：

JOURNAL DE CHIMIE PHYSIQUE ET DE PHYSICO-CHIMIE BIOLOGIQUE | 1994年 / 91卷 / 7-8期

关键词：

IONIZING RADIATION; DNA; PURINE AND PYRIMIDINE BASES; REDUCTION POTENTIALS; ACID/BASE PROPERTIES; ELECTRON-TRANSFER REACTIONS;

D O I：

10.1051/jcp/1994911054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction of ionizing radiation with DNA leads to the creation of radicals whose ESR spectra suggest the presence of guanine cation and thymine anion radicals. Later it was suggested that the cytosine anion could be also present. Recent studies on the reduction potentials of the purine and pyrimidine bases of DNA, their reaction with mild reductants and oxidants and the acid/base properties of their reduced and oxidized radicals had confirmed these ESR conclusions. Based on these findings, we review the possibility of internal electron transfer in DNA and discuss the unique role of the cytosine/guanine pair in this transfer.

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页码：1054 / 1061

页数：8

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