ASYMMETRIC CATALYSIS .87. ENANTIOSELECTIVE ALLYLATION OF 1,5-DIMETHYLBARBITURIC ACID WITH PD CATALYSTS AND NEW OPTICALLY-ACTIVE PN LIGANDS

被引：29

作者：

BRUNNER, H

FURST, J

机构：

[1] Institut für Anorganische Chemie, Universität Regensburg

来源：

INORGANICA CHIMICA ACTA | 1994年 / 220卷 / 1-2期

关键词：

CATALYSIS; ASYMMETRIC CATALYSIS; PALLADIUM COMPLEXES; BARBITURIC ACID; ALLYLATION;

D O I：

10.1016/0020-1693(94)03855-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The new PN ligands 5, 6 and 7 were prepared by Schiff base condensation of 2-formylphenyl(diphenyl)phosphine (1) with the optically active amines (R)-(-)-2-aminobutanol (2), (S)-(+)-2-aminobutanol (3) and (1S,2S)-2-amino-1-phenyl-1,3-propanediol (4). These new ligands were used in the Pd catalysed allylation of 1,5-dimethylbarbituric acid with allylacetate. 5-Allyl-1,5-dimethylbarbituric acid was obtained with an optical induction of up to 12.7% ee.

引用

页码：63 / 66

页数：4

共 15 条

[1] ASYMMETRIC-SYNTHESIS - ASYMMETRIC CATALYTIC ALLYLATION USING PALLADIUM CHIRAL PHOSPHINE COMPLEXES [J].