THE DETECTION OF LATENCY-ASSOCIATED TRANSCRIPTS OF EQUINE HERPESVIRUS-1 IN GANGLIONIC NEURONS

被引:58
作者
BAXI, MK
EFSTATHIOU, S
LAWRENCE, G
WHALLEY, JM
SLATER, JD
FIELD, HJ
机构
[1] UNIV CAMBRIDGE,SCH VET,CTR VET SCI,CAMBRIDGE CB3 0ES,ENGLAND
[2] UNIV CAMBRIDGE,DEPT PATHOL,CAMBRIDGE CB2 1QP,ENGLAND
[3] MACQUARIE UNIV,SCH BIOL SCI,SYDNEY,NSW 2109,AUSTRALIA
关键词
D O I
10.1099/0022-1317-76-12-3113
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Neural tissues from specific pathogen-free ponies that had been experimentally infected with equine herpes-virus 1 (EHV-1) were analysed by in situ hybridization. Digoxigenin-labelled EHV-1 BamHI fragments spanning almost the entire EHV-1 genome were hybridized to RNA in tissue sections from latently infected trigeminal ganglia. The BamHI E fragment detected EHV-1 RNA antisense to gene 63 (HSV-1 homologue ICP0) in a small number of neurons. Sixteen other BamHI fragments gave negative results in 20 sections tested with each fragment. Latency associated transcripts (LATs) were localized to the neuronal nuclei. EHV-I nucleotide sequence data in the region reveals the presence of a putative EHV-1 LAT promoter that shares similar motifs with the HSV-1 LAT promoter, including the LAT promoter-binding factor, and may have a role in EHV-1 LAT expression.
引用
收藏
页码:3113 / 3118
页数:6
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