COGNITIVE IMPAIRMENT IN ALZHEIMERS-DISEASE CORRELATES WITH VENTRICULAR WIDTH AND ATROPHY-CORRECTED CORTICAL GLUCOSE-METABOLISM

被引：2

作者：

SLANSKY, I ^{[1
]}

HERHOLZ, K ^{[1
]}

PIETRZYK, U ^{[1
]}

KESSLER, J ^{[1
]}

GROND, M ^{[1
]}

MIELKE, R ^{[1
]}

HEISS, WD ^{[1
]}

机构：

[1] MAX PLANCK INST NEUROL RES, D-50931 COLOGNE, GERMANY

来源：

NEURORADIOLOGY | 1995年 / 37卷 / 04期

关键词：

BRAIN; MR; POSITRON IMAGING; DEMENTIA; METABOLISM;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We compared the correlation of PET and MRI with neuropsychological tests in 26 patients with probable Alzheimer's disease (AD). The width of the temporal horns and the third ventricle, regional metabolic rates of glucose (rCMRGlu) and the proportion of cerebrospinal fluid space in mesial temporal and temporoparietal cortical regions were measured with three-dimensionally coregistered PET and MRI in two planes perpendicular to the Sylvian fissure. Highly significant correlations between rCMRGlu and neuropsychological tests were found mainly in the temporoparietal cortex, with and without correction for atrophy. Correlations of similar magnitude were seen also between most tests and the width of the temporal horns and third ventricle. Changes in the third ventricle and mesial temporal lobe were best seen with MRI, whereas PET most clearly depicted alterations in neocortical association areas. These two aspects of the disease correlated with the severity of dementia to a similar degree.

引用

页码：270 / 277

页数：8