EFFECT OF EXOGENOUS PHOSPHORYLATED MONOSACCHARIDES ON HORMONE-SENSITIVE LIPOLYSIS IN RAT ADIPOSE-TISSUE

被引：8

作者：

PROSDOCIMI, M ^{[1
]}

CAPARROTTA, L ^{[1
]}

DORIGO, P ^{[1
]}

FASSINA, G ^{[1
]}

SILIPRANDI, N ^{[1
]}

机构：

[1] CNR,CTR STUDIO FISIOL MITOCONDRIALE,I-35100 PADUA,ITALY

来源：

BIOCHEMICAL PHARMACOLOGY | 1979年 / 28卷 / 02期

关键词：

D O I：

10.1016/0006-2952(79)90516-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The activity of glucose-1-phosphate, glucose-6-phosphate, fructose, fructose-1-phosphate, fructose-6-phosphate, and fructose-1,6-diphosphate was tested on rat adipose tissue. The only active one was fructose-1,6-diphosphate (FDP). It slightly increased basal lipolysis and strongly potentiated the lipolytic effect of noradrenaline and theophylline, but not that of dibutyryl cAMP. Furthermore FDP increased basal ATP levels and potentiated cAMP accumulation induced by noradrenaline. Phosphate potentiated the lipolytic effect of noradrenaline but did not increase ATP level. The activity of FDP on lipolysis seems not due to its hydrolytic products and may be related to an increase of ATP availability. © 1979.

引用

页码：281 / 285

页数：5

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