BIOLOGICAL EFFECTS OF AGING ON BONE AND THE CENTRAL-NERVOUS-SYSTEM

被引:4
作者
FUJITA, T
机构
[1] Third Division, Department of Medicine, Kobe University School of Medicine, Chuo-Ku, Kobe City, 650
关键词
aging; calcium; dementia; vitamin D;
D O I
10.1016/0531-5565(90)90068-D
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The skeletal and nervous systems express conspicuous signs of aging in humans in the form of osteoporosis and senile dementia, the most common diseases affecting the elderly population. Although the prevalence of these diseases progressively rises with advancing age, especially in females, the interreletionship between the degenerative changes of the skeletal and nervous systems has not been studied in detail. Defective 1,25(OH)2D synthesis in chronic renal failure is known to cause renal osteodystrophy and is also associated with the appearance of dialysis encephalopathy and a decreased of the conduction velocity of peripheral nerves. Calcium content of the nervous system is increased in this condition, suggesting the existence of generalized abnormalities of calcium metabolism, which affect both the skeletal and nervous system. The mild, chronic renal failure of aging, and the consequent secondary hyperparathyroidism, might therefore contribute to the development of nervous degenerative diseases. © 1990.
引用
收藏
页码:317 / 321
页数:5
相关论文
共 9 条
[1]   CALCIUM-METABOLISM OF BRAIN IN ACUTE RENAL-FAILURE - EFFECTS OF UREMIA, HEMODIALYSIS, AND PARATHYROID-HORMONE [J].
ARIEFF, AI ;
MASSRY, SG .
JOURNAL OF CLINICAL INVESTIGATION, 1974, 53 (02) :387-392
[2]   AGE-RELATED-CHANGES IN PARATHYROID-HORMONE AND 25 HYDROXYCHOLECALCIFEROL LEVELS [J].
CHAPUY, MC ;
DURR, F ;
CHAPUY, P .
JOURNALS OF GERONTOLOGY, 1983, 38 (01) :19-22
[3]   AGE-RELATED-CHANGES IN SERUM IMMUNOREACTIVE PARATHYROID-HORMONE AND ITS BIOLOGICAL ACTION IN HEALTHY-MEN AND WOMEN [J].
ENDRES, DB ;
MORGAN, CH ;
GARRY, PJ ;
OMDAHL, JL .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 65 (04) :724-731
[4]   CALCIUM-METABOLISM IN AGING INHABITANTS OF MOUNTAIN VERSUS SEACOAST COMMUNITIES IN KII PENINSULA [J].
FUJITA, T ;
OKAMOTO, Y ;
TOMITA, T ;
SAKAGAMI, Y ;
OTA, K ;
OHATA, M .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1977, 25 (06) :254-258
[5]   BONE CHANGES AND AORTIC CALCIFICATION IN AGING INHABITANTS OF MOUNTAIN VERSUS SEACOST COMMUNITIES IN THE KII PENINSULA [J].
FUJITA, T ;
OKAMOTO, Y ;
SAKAGAMI, Y ;
OTA, K ;
OHATA, M .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1984, 32 (02) :124-128
[6]  
GADJUSEK DC, 1984, AMYOTROPHIC LATERAL, P145
[7]   EFFECT OF PARATHYROID-HORMONE AND UREMIA ON PERIPHERAL-NERVE CALCIUM AND MOTOR-NERVE CONDUCTION-VELOCITY [J].
GOLDSTEIN, DA ;
CHUI, LA ;
MASSRY, SG .
JOURNAL OF CLINICAL INVESTIGATION, 1978, 62 (01) :88-93
[8]   AGE-RELATED-CHANGES IN PARATHYROID-HORMONE AND PARATHYROID-HORMONE ACTION IN NORMAL HUMANS [J].
MARCUS, R ;
MADVIG, P ;
YOUNG, G .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1984, 58 (02) :223-230
[9]  
YOSHIMASU F, 1976, FOLIA PSYCHIATR NEUR, V30, P52