EFFECT OF ACUTE AND CHRONIC NALOXONE ADMINISTRATION ON MOTOR ACTIVATION IN THE RAT

被引：59

作者：

AMIR, S

SOLOMON, M

AMIT, Z

机构：

[1] Center for Research on Drug Dependence, Department of Psychology, Concordia University, Montreal, Que. H3G 1M8

来源：

NEUROPHARMACOLOGY | 1979年 / 18卷 / 02期

关键词：

D O I：

10.1016/0028-3908(79)90058-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The acute and chronic effects of naloxone on motor activity was studied in rats. No difference in motor activity was noted between naloxone-treated (2.5, 5.0, 10.0 mg/kg) and saline-treated rats on the first day of testing. By contrast, naloxone, in all three doses tested, blocked the increase in motor activation noted in saline-treated animals upon repeated testing. These data may suggest that endogenous opioid systems may play a role in behavioral activation and adaptation and provide further support to the proposed involvement of endogenous ligands for the opiate receptor in emotional reactivity. © 1979.

引用

页码：171 / 173

页数：3

共 22 条

[1] BERNEY S, 1977, COMMUN PSYCHOPHARMAC, V1, P597
[2] NALOXONE AND MORPHINE EFFECTS ON SENSORY-EVOKED RESPONSES
BURKS, TF
DAFNY, N
[J]. NEUROPHARMACOLOGY, 1977, 16 (10) : 681 - 686
[3] OPIATE-INDEPENDENT EFFECTS OF NALOXONE ON CENTRAL NERVOUS-SYSTEM - NEUROPHYSIOLOGICAL APPROACH
DAFNY, N
BURKS, TF
[J]. EXPERIMENTAL NEUROLOGY, 1976, 53 (03) : 633 - 645
[4] INTRAVENOUS NALOXONE ADMINISTRATION IN SCHIZOPHRENIA AND AFFECTIVE-ILLNESS
DAVIS, GC
BUNNEY, WE
DEFRAITES, EG
KLEINMAN, JE
VANKAMMEN, DP
POST, RM
WYATT, RJ
[J]. SCIENCE, 1977, 197 (4298) : 74 - 77
[5] EDDY NB, 1974, NARCOTIC ANTAGONISTS, P9
[6] LACK OF EFFECT OF NALOXONE ON PAIN PERCEPTION IN HUMANS
ELSOBKY, A
DOSTROVSKY, JO
WALL, PD
[J]. NATURE, 1976, 263 (5580) : 783 - 784
[7] INDICATION OF AN ANTIPSYCHOTIC ACTION OF OPIATE ANTAGONIST NALOXONE
EMRICH, HM
CORDING, C
PIREE, S
KOLLING, A
ZERSSEN, DV
HERZ, A
[J]. PHARMAKOPSYCHIATRIE NEURO-PSYCHOPHARMAKOLOGIE, 1977, 10 (05): : 265 - 270
[8] HYPERALGESIA INDUCED BY NALOXONE FOLLOWS DIURNAL RHYTHM IN RESPONSIVITY TO PAINFUL STIMULI
FREDERICKSON, RCA
BURGIS, V
EDWARDS, JD
[J]. SCIENCE, 1977, 198 (4318) : 756 - 758
[9] ENKEPHALIN PENTAPEPTIDES - REVIEW OF CURRENT EVIDENCE FOR A PHYSIOLOGICAL-ROLE IN VERTEBRATE NEUROTRANSMISSION
FREDERICKSON, RCA
[J]. LIFE SCIENCES, 1977, 21 (01) : 23 - 41
[10] ROLE OF ENDOGENOUS OPIOID PEPTIDES - FAILURE OF NALOXONE TO INFLUENCE SHOCK ESCAPE THRESHOLD IN RAT
GOLDSTEIN, A
PRYOR, GT
OTIS, LS
LARSEN, F
[J]. LIFE SCIENCES, 1976, 18 (06) : 599 - 604

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