MDL72222, A SEROTONIN 5-HT3 RECEPTOR ANTAGONIST, BLOCKS MDMAS ABILITY TO ESTABLISH A CONDITIONED PLACE PREFERENCE

被引：52

作者：

BILSKY, EJ ^{[1
]}

REID, LD ^{[1
]}

机构：

[1] RENSSELAER POLYTECH INST,DEPT PSYCHOL,TROY,NY 12180

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 39卷 / 02期

关键词：

METHYLENEDIOXYMETHAMPHETAMINE; MDMA; MDL72222; 5-HT3; RECEPTORS; CONDITIONED PLACE PREFERENCE; AFFECT; REWARD;

D O I：

10.1016/0091-3057(91)90217-P

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Methylenedioxymethamphetamine (MDMA) has previously been shown to produce a positive conditioned place preference (CPP) among rats. Here the effects of doses of a specific 5-HT3 antagonist, MDL72222, on MDMA's ability to produce a CPP were assessed. A dose of MDL72222 (0.03 mg/kg) blocked the establishment of a MDMA CPP. These results support the suggestions that compounds affecting the 5-HT3 receptor may be of particular interest in studying the pharmacology of self-administered drugs.

引用

页码：509 / 512

页数：4

共 24 条

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