ANTIBODY-ASSAYS SUITABLE FOR ASSESSING IMMUNE-RESPONSES TO LIVE VARICELLA VACCINE

被引：96

作者：

PROVOST, PJ

KRAH, DL

KUTER, BJ

MORTON, DH

SCHOFIELD, TL

WASMUTH, EH

WHITE, CJ

MILLER, WJ

ELLIS, RW

机构：

[1] Cellular and Molecular Biology, Merck Sharp and Dohme Research Laboratories, West Point

[2] Clinical Research, Merck Sharp and Dohme Research Laboratories, West Point

[3] Biometrics Research, Merck Sharp and Dohme Research Laboratories, West Point

来源：

VACCINE | 1991年 / 9卷 / 02期

关键词：

VARICELLA VACCINE; ANTIBODY ASSAYS; IMMUNOSORBENT ASSAY;

D O I：

10.1016/0264-410X(91)90266-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An enzyme-linked immunosorbent assay for antibodies to varicella-zoster virus (VZV), using purified viral glycoproteins as antigen (gpELISA), was compared with other assays for measuring vaccine-induced antibody responses. The gpELISA was more sensitive than conventional assays, proved highly specific for VZV and agreed well with an assay for neutralizing antibody activity. It was successfully applied to large-scale testing of live varicella vaccine in humans.

引用

页码：111 / 116

页数：6

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