FURTHER-STUDIES OF THE EFFECTS OF MORPHINE ON THE LEVELS OF MHPG-SO4 IN RAT-BRAIN

被引：14

作者：

ROFFMAN, M ^{[1
]}

REIGLE, T ^{[1
]}

ORSULAK, P ^{[1
]}

CASSENS, G ^{[1
]}

SCHILDKRAUT, JJ ^{[1
]}

机构：

[1] HARVARD UNIV,MASSACHUSETTS MENT HLTH CTR,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02115

来源：

NEUROPHARMACOLOGY | 1979年 / 18卷 / 05期

关键词：

brain; catecholamines; desmethylimipramine; MHPG; morphine; naloxone; norepinephrine; opiates;

D O I：

10.1016/0028-3908(79)90074-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The acute administration of morphine resulted in an increase in the levels of the sulfate conjugate of 3-methoxy-4-hydroxyphenylglycol (MHPG-SO4), a major metabolite of norepinephrine in rat brain. Pretreatment with naloxone, at doses which did not significantly alter MHPG-SO4, attenuated the morphine-induced increase in MHPG-SO4. The morphine-induced increase in levels of MHPG-SO4 was not the result of a drug-induced blockade of the egress of the metabolite from brain, since the rate of disappearance of MHPG-SO4 in animals pretreated with pargyline was similar in morphine-treated and control groups. Moreover, morphine did not inhibit the uptake of intracisternally administered 1-norepinephrine-H3 nor did it produce alterations in norepinephrine-H3 metabolism. With chronic administration of morphine, tolerance developed to the morphine-induced increase in MHPG-SO3 levels in rat brain, and, following cessation of chronic treatment with morphine, the levels of MHPG-SO4 were significantly decreased. © 1979.

引用

页码：483 / 487

页数：5

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