ON THE DEVELOPMENT OF ALTERNATIVE ANTIEPILEPTIC DRUGS - LACK OF ENANTIOSELECTIVITY OF THE ANTICONVULSANT ACTIVITY, IN CONTRAST TO TERATOGENICITY, OF 2-N-PROPYL-4-PENTENOIC ACID AND 2-N-PROPYL-4-PENTYNOIC ACID, ANALOGS OF THE ANTICONVULSANT DRUG VALPROIC ACID

被引：13

作者：

HAUCK, RS ^{[1
]}

NAU, H ^{[1
]}

ELMAZAR, MMA ^{[1
]}

机构：

[1] MANSOURA UNIV,FAC PHARM,DEPT PHARMACOL & TOXICOL,MANSOURA,EGYPT

来源：

NATURWISSENSCHAFTEN | 1991年 / 78卷 / 06期

关键词：

D O I：

10.1007/BF01134356

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

[No abstract available]

引用

页码：272 / 274

页数：3

共 17 条

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[2]

HAUCK R-S, 1990, Teratology, V41, P563

[3] STRUCTURAL BASIS FOR THE TERATOGENIC EFFECT OF THE ANTIEPILECTIC VALPROIC ACID (VPA) - 2-N-PROPYL-4-PENTINOIC ACID, THE 1ST STRUCTURAL ANALOG WITH SIGNIFICANTLY HIGHER TERATOGENIC ACTIVITY THAN VPA [J].

HAUCK, RS ;

NAU, H .

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[4] ASYMMETRIC-SYNTHESIS AND ENANTIOSELECTIVE TERATOGENICITY OF 2-N-PROPYL-4-PENTENOIC ACID (4-EN-VPA), AN ACTIVE METABOLITE OF THE ANTICONVULSANT DRUG, VALPROIC ACID [J].

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NAU, H .

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NAU, H ;

HELGE, H .

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[6] ENANTIOSELECTIVE ASPECTS OF DRUG-ACTION AND DISPOSITION - THERAPEUTIC PITFALLS [J].

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MEHVAR, R ;

PASUTTO, FM .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1989, 78 (09) :695-715

[7] THE EFFECTS OF ANALOGS OF VALPROIC ACID ON SEIZURES INDUCED BY PENTYLENETETRAZOL AND GABA CONTENT IN BRAIN OF MICE [J].

KEANE, PE ;

SIMIAND, J ;

MENDES, E ;

SANTUCCI, V ;

MORRE, M .

NEUROPHARMACOLOGY, 1983, 22 (07) :875-879

[8] CHIRALITY - CLINICAL PHARMACOKINETIC AND PHARMACODYNAMIC CONSIDERATIONS [J].

LEE, EJD ;

WILLIAMS, KM .

CLINICAL PHARMACOKINETICS, 1990, 18 (05) :339-345

[9]

LINDHOUT D, 1984, LANCET, V2, P396

[10]

LINDHOUT D, 1986, LANCET, V1, P1392

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