PROLACTIN RESPONSE TO LOW-DOSE HALOPERIDOL CHALLENGE IN SCHIZOPHRENIC, NONSCHIZOPHRENIC PSYCHOTIC, AND CONTROL SUBJECTS

被引:10
作者
COPOLOV, DL [1 ]
KEKS, NA [1 ]
KULKARNI, J [1 ]
SINGH, BS [1 ]
MCKENZIE, D [1 ]
MCGORRY, P [1 ]
HILL, C [1 ]
机构
[1] MONASH UNIV,ROYAL PK HOSP,DEPT PSYCHOL,PARKVILLE,VIC,AUSTRALIA
关键词
D O I
10.1016/0306-4530(90)90033-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Haloperidol was administered IV to 46 male psychotic inpatients and 28 male control subjects. A two-way analysis of covariance, with age as the covariate, revealed that DSM-III schizophrenics (n=27) had a lower prolactin response to haloperidol than did the controls (n=28). There were no significant differences between the prolactin responses in schizophrenics, patients with affective disorders (n=7), and those with other psychoses (n=12), which included patients with paranoia, schizophreniform, schizoaffective disorder, and atypical psychoses. These findings support the proposition that tuberoinfundibular dopaminergic dysfunction may occur in certain patients with DSM-III schizophrenia. © 1990.
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收藏
页码:225 / 231
页数:7
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