DNA STRAND BREAKAGE BY PEROXIDASE-ACTIVATED MITOXANTRONE

被引：25

作者：

FISHER, GR ^{[1
]}

PATTERSON, LH ^{[1
]}

机构：

[1] CITY LEICESTER POLYTECH,DEPT PHARM,LEICESTER LE1 9BH,ENGLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 01期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb05455.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Spectroscopic evidence demonstrates that the alkylaminoanthraquinone mitoxantrone is a substrate for horseradish peroxidase in the presence of hydrogen peroxide and that the result of this interaction is the formation of an air-stable mitoxantrone-derived free radical. The mitoxantrone-derived free radicals or their further oxidation products appear to extensively cross-link with plasmid DNA by a reaction that is mitoxantrone concentration-dependent. Oxidative activation of mitoxantrone to a DNA-damaging species may contribute to the mechanism of action of this antitumour agent.

引用

页码：65 / 68

页数：4

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