HYPOTHALAMIC-PITUITARY FUNCTION IN CUSHINGS-DISEASE

被引：3

作者：

LEROITH, D ^{[1
]}

SHAPIRO, MS ^{[1
]}

GUTMAN, A ^{[1
]}

SPITZ, IM ^{[1
]}

机构：

[1] SHAARE ZEDEK MED CTR,DEPT ENDOCRINOL & METAB,POB 293,JERUSALEM 9100,ISRAEL

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 1979年 / 2卷 / 04期

关键词：

Cushing’s disease; FSH; GH; LH; PRL; TSH;

D O I：

10.1007/BF03349337

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypothalamic pituitary function was evaluated in seven patients with Cushing’s disease. In all subjects there was an absence of GH elevation following hypoglycemia. Three patients demonstrated basal hyperprolactinemia. Six had an intact PRL rise following TRH. However, four patients failed to show PRL elevation with insulin hypoglycemia and six were unresponsive to chlorpromazine. Five patients showed impaired TSH response to TRH. Many of the subjects had low basal LH and FSH levels. Attenuated or absent gonadotropin responses to LHRH were noted in three females. One male demonstrated an exaggerated FSH response to LHRH. These results indicate that multiple abnormalities of anterior pituitary hormone secretion characterize Cushing’s disease. © 1978, Italian Society of Endocrinology (SIE). All rights reserved.

引用

页码：379 / 383

页数：5

共 16 条

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