INTRACELLULAR BORON LOCALIZATION AND UPTAKE IN CELL-CULTURES USING IMAGING SECONDARY ION MASS-SPECTROMETRY (ION MICROSCOPY) FOR NEUTRON-CAPTURE THERAPY FOR CANCER

被引：25

作者：

BENNETT, BD ^{[1
]}

ZHA, XH ^{[1
]}

GAY, I ^{[1
]}

MORRISON, GH ^{[1
]}

机构：

[1] CORNELL UNIV,DEPT CHEM,ITHACA,NY 14853

来源：

BIOLOGY OF THE CELL | 1992年 / 74卷 / 01期

基金：

美国国家科学基金会;

关键词：

SIMS MICROSCOPY; BORON NEUTRON CAPTURE THERAPY DRUGS; SUBCELLULAR;

D O I：

10.1016/0248-4900(92)90015-S

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Quantitative ion microscopy of freeze-fractured, freeze-dried cultured cells is a technique for single cell and subcellular elemental analysis [1 - 3]. This review describes the technique and its usefulness in determining the uptake and subcellular distribution of the boron from boron neutron capture therapy drugs.

引用

页码：105 / 108

页数：4

共 12 条

[1] QUANTITATIVE IMAGING OF BORON, CALCIUM, MAGNESIUM, POTASSIUM, AND SODIUM DISTRIBUTIONS IN CULTURED-CELLS WITH ION MICROSCOPY [J].

AUSSERER, WA ;

LING, YC ;

CHANDRA, S ;

MORRISON, GH .

ANALYTICAL CHEMISTRY, 1989, 61 (24) :2690-2695

[2]

AUSSERER WA, 1988, J MICROSC-OXFORD, V154, P39

[3]

BARTH RF, 1990, CANCER RES, V50, P1061

[4] EVALUATION OF MATRIX EFFECTS IN ION MICROSCOPIC ANALYSIS OF FREEZE-FRACTURED, FREEZE-DRIED CULTURED-CELLS [J].

CHANDRA, S ;

AUSSERER, WA ;

MORRISON, GH .

JOURNAL OF MICROSCOPY-OXFORD, 1987, 148 :223-239

[5] ION MICROSCOPY IN BIOLOGY AND MEDICINE [J].

CHANDRA, S ;

MORRISON, GH .

METHODS IN ENZYMOLOGY, 1988, 158 :157-179

[6]

CODERRE JA, 1987, CANCER RES, V47, P6377

[7]

PAWLEK JM, 1973, YALE J BIOL MED, V46, P430

[8] 4-NORLEUCINE, 7-D-PHENYLALANINE-ALPHA-MELANOCYTE-STIMULATING HORMONE - A HIGHLY POTENT ALPHA-MELANOTROPIN WITH ULTRALONG BIOLOGICAL-ACTIVITY [J].

SAWYER, TK ;

SANFILIPPO, PJ ;

HRUBY, VJ ;

ENGEL, MH ;

HEWARD, CB ;

BURNETT, JB ;

HADLEY, ME .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (10) :5754-5758

[9] SUBCELLULAR LOCALIZATION OF MALANIN BIOSYNTHESIS [J].

SEIJI, M ;

FITZPATRICK, TB ;

BIRBECK, MSC ;

SHIMAO, K .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1963, 100 (02) :497-&

[10]

SOLOWAY AH, 1991, IN PRESS NEUTRON CAP

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